Project-team Sigma2
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Short- and long-term reproducibility of the 1-h 50-g glucose challenge test.
A study was undertaken to assess the short-term (intrapregnancy) and long-term (interpregnancy) variability of the 1-h 50-g oral glucose challenge test (GCT). Two groups of pregnant women had GCTs in consecutive pregnancies, 1 (n = 77) and 2 (n = 43) years apart. Their results were compared with published results for a group (n = 53) who had GCTs on consecutive days. Robust estimates of the mea...
متن کاملEffects on phenotypic variability of directional selection arising through genetic differences in residual variability.
In standard models of quantitative traits, genotypes are assumed to differ in mean but not variance of the trait. Here we consider directional selection for a quantitative trait for which genotypes also confer differences in variability, viewed either as differences in residual phenotypic variance when individual loci are concerned or as differences in environmental variability when the whole g...
متن کاملCloning the sigma2 receptor: Wandering 40 years to find an identity.
Scientists have endeavored to understand sigma receptors for over 40 y. Althoughmost agree that they are important, there is little agreement on anything else. In their behavioral classification of opioid receptors in 1976, Martin et al. (1) proposed three groups of compounds illustrating three distinct opioid receptor classes (mu, kappa, and sigma) based upon morphine, ketocyclazocine, and SKF...
متن کاملContemporary methods for evaluating complex project proposals
The ability to evaluate project proposals, assessing future success, and organizational value is critical to overall business performance for most enterprises. Yet, predicting project success is difficult and often unreliable. A four-year field study shows that the effectiveness of available methods for evaluating and selecting large, complex project depends on the specific project type, org...
متن کاملThe hydrophilic amino-terminal arm of reovirus core shell protein lambda1 is dispensable for particle assembly.
The reovirus core particle is a molecular machine that mediates synthesis, capping, and export of the viral plus strand RNA transcripts. Its assembly and structure-function relationships remain to be well understood. Following the lead of previous studies with other Reoviridae family members, most notably orbiviruses and rotaviruses, we used recombinant baculoviruses to coexpress reovirus core ...
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